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Am J Perinatol 2018; 35(09): 904-910
DOI: 10.1055/s-0038-1626712
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Amplitude-Integrated EEG and Cerebral Near-Infrared Spectroscopy in Cooled, Asphyxiated Infants

C. K. Niezen
1   Division of Neonatology, Department of Pediatrics, Beatrix Children's Hospital, University of Groningen, University Medical Center Groningen, The Netherlands
2   Department of Anesthesiology, University of Groningen, University Medical Center Groningen, The Netherlands
,
A. F. Bos
1   Division of Neonatology, Department of Pediatrics, Beatrix Children's Hospital, University of Groningen, University Medical Center Groningen, The Netherlands
,
D. A. Sival
1   Division of Neonatology, Department of Pediatrics, Beatrix Children's Hospital, University of Groningen, University Medical Center Groningen, The Netherlands
,
L. C. Meiners
3   Department of Radiology, University of Groningen, University Medical Center Groningen, The Netherlands
,
H. J. ter Horst
1   Division of Neonatology, Department of Pediatrics, Beatrix Children's Hospital, University of Groningen, University Medical Center Groningen, The Netherlands
› Author Affiliations
Further Information

Publication History

30 June 2017

29 December 2017

Publication Date:
08 February 2018 (online)

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Abstract

Objective To assess the predictive value of amplitude-integrated electroencephalography EEG (aEEG) and near-infrared spectroscopy (NIRS) during therapeutic hypothermia.

Patients and Methods We studied 39 cooled, asphyxiated infants. We assessed aEEG and calculated mean regional cerebral oxygen saturation (rcSO2) during and after treatment. At 30 months, we performed a neurological examination and administered the Bayley Scales of Infant and Toddler Development, 3rd edition. We calculated the odds ratios (ORs) of abnormal aEEG and rcSO2 for severely abnormal outcome.

Results At 6 and 12 hours, severely abnormal aEEGs predicted severely abnormal outcomes (OR, 7.7 [95% confidence interval, CI, 1.39–42.6] and 24.4 [95% CI 4.2–143] respectively), as did epileptic activity (OR 28.9, 4.6–183). During the first 48 hours, rcSO2 was not associated with outcome, but at 72 hours after birth and after rewarming it was, with ORs for severely abnormal outcomes of 12.8 (1.31–124) and 21.6 (1.05–189), respectively. In multivariate analyses, aEEG and rcSO2 remained independently predictive in the model at 48 hours and significantly from 72 hours after birth onward.

Conclusion aEEG was a strong predictor of adverse outcome. After 48 hours of cooling, a higher rcSO2 was associated with a severely abnormal outcome, adding to the predictive value of aEEG in cooled, asphyxiated infants.

Keywords

aEEG - NIRS - MRI - therapeutic hypothermia - asphyxia - newborns